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ea0063gp7 | Adrenal and Neuroendocrine - Tumour | ECE2019

Parafibromin is regulated by ubiquitin specific protease 37 (USP37) and the c-terminus of USP37 interacts with the beta-catenin binding region of CDC73 in hyperparathyroidism-jaw tumor syndrome

Kim Su Yeon , Lee Ji-young , Jo Kwan Hoon , Mo Eun Yeong , Kim Eun Sook , Han Je Ho , Baek Kwang-Hyun

CDC73 (also known as HRPT2) encodes parafibromin and is known to be the causative gene of hyperparathyroidism-jaw tumor (HPT-JT) syndrome. There is no known ubiquitination of parafibromin, and the deubiquitinating enzyme (DUB) for parafibromin has not been identified to date. Full-length DUB cDNAs encoding 58 family members of ubiquitin specific proteases (USPs) were subcloned. The DUB cDNA was used to identify parafibromin interacting by yeast two-hybrid screening. W...

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Endocrine Abstracts

Parafibromin is regulated by ubiquitin specific protease 37 (USP37) and the c-terminus of USP37 interacts with the beta-catenin binding region of CDC73 in hyperparathyroidism-jaw tumor syndrome

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